Gen-COVID

Working on COVID-19 since January 2020, at the time of our kick-off meeting in Brussels related to our European project DIAMONDS on infectious diseases.

Our web-site is open since already a few months: GEN-COVID. Please, visit it and have a look at the different areas we are working with on COVID-19. A brief summary:

OMICS on the host:

  • Genomics. Genetic markers of susceptibility and prognosis of COVID-19 infection
  • Transcriptomics. Local and systemic transcriptomic signatures that allow the accurate differential diagnosis of COVID-19 infection at different timepoints of infection, as well as establish prognostic markers for its natural history. Differential expression patterns in different host samples
  • Epigenomics. Understanding the role of epigenomics in COVI-19
  • Proteomics. Patterns in different host samples and at different stages of the infection

Inmunology. Soluble biomarkers related to the immune system that allow us to characterize and predictthe immune response to COVID-19

OMICS on the pathogene. Understanding genome variation of CoV-2

CRISPR experiments on diagnosis and detection of the pathogene

Publications of the group related to COVID-19/SARS-CoV-2

  • Bello X, Pardo-Seco J, Gomez-Carballa A, Weissensteiner H, Martinon-Torres F, Salas A. 2022. CovidPhy: A tool for phylogeographic analysis of SARS-CoV-2 variation. Environ Res 204: 111909.
  • Dacosta-Urbieta A, Rivero-Calle I, Pardo-Seco J, Redondo-Collazo L, Salas A, Gomez-Rial J, Martinon-Torres F. 2020. Seroprevalence of SARS-CoV-2 Among Pediatric Healthcare Workers in Spain. Front Pediatr 8: 547.
  • Gómez-Carballa A, Bello X, Pardo-Seco J, Martinón-Torres F, Salas A. 2020a. Mapping genome variation of SARS-CoV-2 worldwide highlights the impact of COVID-19 super-spreaders. Genome Res 30: 1434-1448.
  • Gómez-Carballa A, Bello X, Pardo-Seco J, Pérez Del Molino ML, Martinón-Torres F, Salas A. 2020b. Phylogeography of SARS-CoV-2 pandemic in Spain: a story of multiple introductions, micro-geographic stratification, founder effects, and super-spreaders. Zool Res 41: 605-620.
  • Gomez-Carballa A, Martinon-Torres F, Salas A. 2022a. Is SARS-CoV-2 an oncogenic virus? J Infectdoi:10.1016/j.jinf.2022.08.005.
  • Gomez-Carballa A, Pardo-Seco J, Bello X, Martinon-Torres F, Salas A. 2021. Superspreading in the emergence of COVID-19 variants. Trends Genet 37: 1069-1080.
  • Gomez-Carballa A, Pardo-Seco J, Pischedda S, Rivero-Calle I, Butler-Laporte G, Richards JB, Viz-Lasheras S, Martinon-Torres F, Salas A, network G. 2022b. Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomics. Environ Res 215: 114288.
  • Gómez-Carballa A, Rivero-Calle I, Pardo-Seco J, Gómez-Rial J, Rivero-Velasco C, Rodriguez-Nunez N, Barbeito-Castineiras G, Pérez-Freixo H, Cebey-López M, Barral-Arca R et al. 2022. A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity. Environ Res 210: 112890.
  • Gomez-Rial J, Curras-Tuala MJ, Rivero-Calle I, Gomez-Carballa A, Cebey-Lopez M, Rodriguez-Tenreiro C, Dacosta-Urbieta A, Rivero-Velasco C, Rodriguez-Nunez N, Trastoy-Pena R et al. 2020a. Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology. Frontiers in immunology 11: 560381.
  • Gomez-Rial J, Rivero-Calle I, Salas A, Martinon-Torres F. 2020b. Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy. Infect Drug Resist 13: 2485-2493.
  • Jackson H, Rivero-Calle I, Broderick C, Habgood‑Coote D, D’Souza G, Nichols S, Vito O, Gómez‑Rial J, Rivero‑Velasco C, Rodríguez‑Núñez N et al. 2022. Characterisation of the blood RNA host response underpinning severity in COVID‑19 patients. Sci Rep 12: 12216.
  • Pardo-Seco J, Gomez-Carballa A, Bello X, Martinon-Torres F, Salas A. 2021. Pitfalls of barcodes in the study of worldwide SARS-CoV-2 variation and phylodynamics. Zool Res 42: 87-93.
  • Salas A, Bello X, Pardo-Seco J, Martinón-Torres F, Gómez-Carballa A. 2021. Superspreading: The engine of the SARS-CoV-2 pandemic. Sciencehttps://science.sciencemag.org/content/early/2020/12/09/science.abe3261/tab-e-letters.
  • Antonio Salas - reportaje Fundación QUAES: "SARS-CoV-2 y el gran experimento global"

COVID19hg

We are partners with our GEN-COVID project in the macro-project COVID19hg (see partners here).

[GenCovidHP image]

Coming soon:

Agreements with the industry

Also running some collaboration and agreement with the industry. More information hopefully soon!!

GenPoB on the news in regards to COVID-19

A non-updated list of links covering our role in the media during the pandemic (basically, the period 2020-2021)

Please, visit the section "News" for more updated information in this regard.

  • Los gemelos: una posible respuesta genética al coronavirus. Click
  • Trazan el árbol genealógico del virus con todos sus «descendientes» por el mundo. Click (if you do not have access try here)
  • On the radio - CRTVG: go to min 19

NEWS!! In regards to our article:The impact of super-spreaders in COVID-19: mapping genome variation worldwide

See metric to our article here

National press

Regional press

Internacional press

On TV

Radio

Science magazines

Facebook

  • Ebiotec - Eurospes Biotecnologia S.A.

Other related interviews

La Voz de Galicia (2 October, 2020): La herencia genética de los neandertales influye en la mayor gravedad del covid-19

Los Angeles Times (1st October, 2020): A mini-interview by Shashank Bengali in regards to a paper in Science on super-spreaders in India nicely covered by Shashank: "Largest study of COVID-19 transmission highlights essential role of super-spreaders"